Uptake of low-density lipoprotein (LDL) particles by macrophages represents a key step in the development of atherosclerotic plaques, leading to the foam cell formation. Chemical modification of LDL is however necessary to induce this…
Since the beginning of the 1990s, researchers from the Endocrinology and Nutrition Service of the Cardiovascular Biochemistry group have collaborated in the study of lipid metabolism and cardiovascular risk factors in patients with diabetes…
Epoxyeicosatetraenoic acids (EEQs or Epetes) are a set of biologically active epoxides that various cell types make by metabolizing the omega 3 fatty acid, eicosapentaenoic acid (EPA), with certain cytochrome P450 epoxygenases.
Gonadal steroid hormones have been suggested as the underlying mechanism responsible for the sexual dimorphism observed in metabolic diseases. Animal studies have also evidenced a causal role of the gut microbiome and metabolic health.
How should we understand the totality of the evidence for this research question (RQ)? We find it helpful to break this overarching RQ down into at least three sub-RQs that will then constitute the core framework – the causal model – by…