Pamplona | Vševěd.cz
Pamplona, provinční m. v sv. Španělsku v provincii Navarra, 451 m. n.m.; 183 964 obyv. (2001) srov. 177 900 obyv. (1981). Arch. památky. Muzea, archív, knihovna. - P. zal. 75-74 př.n.l.
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Ketone bodies as signaling metabolites - PMC
Traditionally, the ketone body β-hydroxybutyrate (βOHB) has been looked upon as a carrier of energy from liver to peripheral tissues during fasting or exercise. However, βOHB also signals via extracellular receptors and acts as an…
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Biomarkers of ageing in Drosophila - PMC
Low environmental temperature and dietary restriction (DR) extend lifespan in diverse organisms. In the fruit fly Drosophila, switching flies between temperatures alters the rate at which mortality subsequently increases with age but does…
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Manipulating mtDNA in vivo reprograms metabolism v…
DNA cleavage activity induced a type II diabetes-like phenotype involving deactivation of Akt kinase and inhibition of pyruvate dehydrogenase, whilst translocation decreased post-translational protein acetylation by cytonuclear depletion of…
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DNA Damage and Base Excision Repair in Mitochondria and Their…
During the last decades, our knowledge about the processes involved in the aging process has exponentially increased. However, further investigation will be still required to globally understand the complexity of aging.
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Adenosine A2A receptor - Wikipedia
Blockade of A2AR has been attempted to various ends, namely cancer immunotherapy. While several A2A receptor antagonists have progressed to clinical trials for the treatment of Parkinson's disease, A2AR blockade in the context of cancer is…
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Monounsaturated Fatty Acids in Obesity-Related Inflammation…
Obesity is an important aspect of the metabolic syndrome and is often associated with chronic inflammation. In this context, inflammation of organs participating in energy homeostasis (such as liver, adipose tissue, muscle and pancreas…
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Long-Term Supplementation With Resveratrol Alleviates Oxidative…
This study analyzed the capacity of resveratrol, a naturally occurring polyphenol, to reduce aging-induced oxidative stress and protect against sarcopenia. Middle-aged (18 months) C57/BL6 mice were randomly assigned to receive either a…
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