In 2015–16 Primera División de Fútbol Profesional season, between Apertura and Clausura seasons, Juventud Independiente sold it's spot to Segunda División (and former Primera División) side C.D.
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A key limitation to the use of Crispr-Cas9 proteins for genome editing and other applications is the requirement that a protospacer adjacent motif (PAM) be present at the target site.
Low concordance between studies that examine the microbiota in human diseases is a pervasive challenge that limits capacity to identify causal relationships between host-associated microbes and pathology.
The dinoflagellates are an ecologically important group of microbial eukaryotes that have evolved many novel genomic characteristics. They possess some of the largest nuclear genomes among eukaryotes arranged on permanently condensed
What distinct genomic features are observed in dinoflagellates compared to other eukaryotes?Dinoflagellates possess permanently condensed chromosomes lacking nucleosomes, and their genomes may exceed 185 Gb in size. They also exhibit unique nucleobases like hydroxymethyluracil, accounting for over 35% of thymine in their DNA.How does lateral gene transfer (LGT) influence dinoflagellate gene content?LGT has significantly contributed to the gene portfolio of dinoflagellates, introducing essential traits such as histone-like proteins and form II RuBisCO from proteobacteria. The extent of this influence is gradually being unveiled through phylogenomic analyses.What evolutionary processes drive genome evolution in dinoflagellates?Both gene duplication and lateral gene transfer are key processes in dinoflagellate genome evolution, facilitating the emergence of novel traits. Phylogenomic studies are identifying a major impact of LGT on the dinoflagellate lineage.
Chronic effects of Covid-19 can lead to a prolonged inflammatory state, which can increase symptoms resembling an autoimmune disorder. [1 ] Many patients with Covid-19 experience psychological symptoms that can arise either from the direct…
Histone to protamine exchange and the hyperacetylation of the remaining histones are hallmarks of spermiogenesis. Acetylation of histone H4 at lysine 12 (H4K12ac) was observed prior to full decondensation of sperm chromatin after…