f74e6e32-ee6f-4e7c-8224-8dcc9fd5e9b1 | Tgacv
Střední škola technická, gastronomická a automobilní, Chomutov, příspěvková organizace
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Human papillomavirus E6 and Myc proteins associate in vivo and…
The papillomavirus E6 protein binds and directs the ubiquitin-dependent degradation of the p53 tumor suppressor protein. Independent of this p53-degradative function, however, E6 induces cellular telomerase activity.
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Sulforaphane Inhibits c-Myc-Mediated Prostate Cancer Stem-Like…
Preventive and therapeutic efficiencies of dietary sulforaphane (SFN) against human prostate cancer have been demonstrated in vivo, but the underlying mechanism(s) by which this occurs is poorly understood.
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Myc and Mad Bhlhz domains possess identical DNA-binding…
The opposing transcriptional activities of the basic-helix–loop–helix-leucine zipper proteins Myc and Mad, taken together with information related to their expression patterns and biological effects, have led to a model of the Myc/Max/Mad…
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Model organism - Wikipedia
A model organism is a non-human species that is extensively studied to understand particular biological phenomena, with the expectation that discoveries made in the model organism will provide insight into the workings of other organisms…
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Myc activates telomerase - PMC
Telomere maintenance has been proposed as an essential prerequisite to human tumor development. The telomerase enzyme is itself a marker for tumor cells, but the genetic alterations that activate the enzyme during neoplastic transformation…
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Myc Stimulates Nuclearly Encoded Mitochondrial Genes and…
Although several genes involved in mitochondrial function are direct Myc targets, the role of Myc in mitochondrial biogenesis has not been directly established. We determined the effects of ectopic Myc expression or the loss of Myc on…
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Oncogenic PKA signaling increases c-MYC protein expression…
Protein kinase A-driven increases in c-MYC protein expression and tumor cell proliferation can be blocked by eIF4A inhibitors, suggesting a potential new treatment option for patients with oncogenic PKA activation.
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Targeting the MYC oncogene with a selective bi-steric Mtorc1…
The MYC oncogene is causally involved in the pathogenesis of most human cancers. The Mtorc1 complex regulates MYC translation through 4EBP1 and S6K. However, agents that selectively target Mtorc1 (without affecting Mtorc2) have so far failed…
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Workshop: A Web-Based Tool for Autism Research and the…
The upcoming workshop will discuss objectives, scope, tool entities, and user experiences, aiming to create a valuable resource that resonates with diverse perspectives within the ASD community.
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