Reactive astrocytes are strongly induced by central nervous system (CNS) injury and disease but their role is poorly understood. Here we show that A1 reactive astrocytes are induced by classically-activated neuroinflammatory microglia.
Steven Frank, Professor (Full) | Cited by 14,520 | of University of Texas MD Anderson Cancer Center, Houston (MD Anderson) | Read 766 publications | Contact Steven Frank
Broadly concordant with human data, in a mouse model of Huntington’s disease (HD), pathophysiology and its genetic attenuation were accompanied by altered and restored CS SPAN and CSPs, respectively.