Global analysis of p53-regulated transcription identifies its…

The first global analysis of the effects of the transcription factor p53 on RNA synthesis illuminates several novels aspects of the molecular mechanism of action of this potent tumor suppressor.
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Anti-Proliferative Activities of Sinigrin on Carcinogen-Induced…

Liver cancer is one of the leading causes of cancer death worldwide. A very high incidence of new liver cancer cases is diagnosed every year, and metastasis has been found to correlate to poor prognoses in humans.
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Selective Regulation of Bone Cell Apoptosis by Translational…

Glucocorticoids are widely used in the treatment of inflammatory and other diseases. However, high-dose or chronic administration often triggers troublesome side effects such as metabolic syndrome and osteoporosis.
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Object Oriented UX Podcasts | OOUX

Every 3rd Thursday afternoon, take a dive into the weeds on UX systems, information architecture, human psychology, data wrangling, structured content, UX process.
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ATR inhibition selectively sensitizes G1 checkpoint-deficient…

Premature chromatin condensation (PCC) is a hallmark of mammalian cells that begin mitosis before completing DNA replication. This lethal event is prevented by a highly conserved checkpoint involving an unknown, caffeine-sensitive mediator…
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TopBP1 Governs Hematopoietic Stem/Progenitor C…

These studies therefore emphasized the importance of topbp1 function as well as DNA damage response pathways during the fetal HSPC rapid proliferation.
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Increased Sensitivity to UV Radiation in Mice with a p53 Point…

Phosphorylation is important for p53 protein stabilization and activation after DNA damage. Serine 389 of p53 is specifically phosphorylated after UV irradiation, whereas gamma radiation activates p53 through a different pathway.
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Alan Moody | Fellow | PhD | University of Plymouth, Plymouth…

Alan Moody, Fellow | Cited by 3,115 | of University of Plymouth, Plymouth (UoP) | Read 119 publications | Contact Alan Moody
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Audrey PAPP | Lab Technical Director | B.S. Medical Technology…

I have been involved in personalized medicine, biomarker discovery, and human diagnostics for many years at The Ohio State University. As lab technical director I’ve led in the evaluation, development and implementation of NGS sequencing.
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Corp Regulates P53 in via a Negative Feedback Loop | proLékaře…

1. Zhou B-BS, Elledge SJ (2000) The DNA damage response: putting checkpoints in perspective.
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