Rapidly proliferating cells switch from oxidative phosphorylation to aerobic glycolysis plus glutaminolysis, markedly increasing glucose and glutamine catabolism. Although Otto Warburg first described aerobic glycolysis in cancer cells >90…
Oxidative stress and metabolic dysregulation of the RPE have been implicated in AMD; however, the molecular regulation of RPE metabolism remains unclear. The transcriptional coactivator, peroxisome proliferator-activated receptor-gamma…
In August 2024, researchers with the Texas Comptroller of Public Accounts released the Housing Affordability Challenge (PDF), examining the factors leading to the rapid decline in affordability in Texas and across the U.S.
Progressive loss of T cell functionality is a hallmark of chronic infection with human immunodeficiency virus 1 (HIV-1). We have identified a novel population of dysfunctional T cells marked by surface expression of the glycoprotein Tim-3.
Eugene Maraskovsky, Executive Director | Cited by 22,909 | of University of Melbourne, Melbourne (MSD) | Read 187 publications | Contact Eugene Maraskovsky
T cell receptor (TCR) signaling plays a key role in T cell fate determination. Precursor cells expressing TCRs within a certain low affinity range for self peptide-MHC complexes undergo positive selection and differentiate into naïve T…