My research integrates veterinary medicine, virology, and cancer biology to explore tumorigenesis across species. I am deeply engaged in investigating the molecular mechanisms underlying tumor progression, viral oncogenesis, and tumor–host…
By employing high-field fMRI to measure connectivity with the hippocampus and adjacent parahippocampal structures within the medial temporal lobe, it is shown that the entorhinal cortex can be divided into anterior-lateral and posterior…
By incorporating a de novo-designed fibroblast growth factor receptor (FGFR)-binding module into these scaffolds, we generated a series of synthetic signaling ligands that exhibit potent valency- and geometry-dependent Ca2+ release and…
The p16INK4A and p14ARF proteins, encoded by the INK4A-ARF locus, are key regulators of cellular senescence, yet the mechanisms triggering their up-regulation are not well understood.
Replicative cellular senescence is an important tumor suppression mechanism and also contributes to aging. Progression of both cancer and aging include significant epigenetic components, but the chromatin changes that take place during…
FOIA Log FY 2019 - Free download as PDF File (.pdf), Text File (.txt) or view presentation slides online. This document is a log of Freedom of Information Act requests received by the U.S.
We show that ZEB2 promotes neuroepithelial transition, and its manipulation and downstream signaling leads to acquisition of nonhuman ape architecture in the human context and vice versa, establishing an important role for neuroepithelial…