Perturb-seq: Dissecting molecular circuits with scalable single…
Genetic screens help infer gene function in mammalian cells, but it has remained difficult to assay complex phenotypes – such as transcriptional profiles – at scale. Here, we develop Perturb-seq, combining single cell RNA-seq and Crispr…
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Egg Allergy in US Children - PMC
Egg allergy is common in young children (<5 years) and has significant negative impacts on quality of life. The objective of this study was to characterize egg allergy prevalence, severity, baked egg tolerance, and other associated factors…
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Live imaging endogenous transcription factor dynamics reveals…
Interestingly, this trajectory can switch during a defined developmental window, leading to the emergence of secondary EPI cells.
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Evolutionary trends in host physiology outweigh dietary niche…
Over the past decade several studies have reported that the gut microbiomes of mammals with similar dietary niches exhibit similar compositional and functional traits. However, these studies rely heavily on samples from captive individuals…
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European Revolutions
Three Phases of European and World Revolution With particular attention to war and revolution [wrx&REV] 2010-2015 Kimball Files Table of Contents = (0) Definitions = Revolution | modern total war (1) Phase One = The Liberal Revolution…
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Conditions for transplantation of primordial germ cells in the…
Coelho G. C. Z., Carvalho G. B., Monzani P. S., Lopez L. S., do Nascimento N. F., Senhorini J. A., Yasui G. S. (2023). Conditions for transplantation of primordial germ cells in the yellowtail tetra, Astyanax altiparanae.
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Centrosomal Proteins CG-NAP and Kendrin Provide Microtubule…
Microtubule assembly is initiated by the γ-tubulin ring complex (γ-TuRC). In yeast, the microtubule is nucleated from γ-TuRC anchored to the amino-terminus of the spindle pole body component Spc110.
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Posterová Sekce | proLékaře.cz
Borský P1, Holmannová D1, Andrýs C2, Kremláček J3, Fiala Z1, Řeháček V4, Esterková M1, Počtová G1, Švadláková T1, Blaha V5, Soukup T1, Marešová T1, Borská L1
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RIF1 controls replication timing in early mouse embryos…
However, the molecular regulators are unknown. Here, by combining loss-of-function analysis with genome-wide investigation of RT in mouse embryos, we identify Rap1 interacting factor 1 (RIF1) as a regulator of the progressive consolidation…
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