There are fifteen different DNA polymerases encoded in mammalian genomes, which are specialized for replication, repair or the tolerance of DNA damage. New evidence is emerging for lesion-specific and tissue-specific functions of DNA…
DNA damages cause changes in the structure of the genetic material and prevents the replication mechanism from functioning and performing properly. [1 ] The DNA damage response (DDR) is a complex signal transduction pathway which recognizes…
Las diferentes confesiones tienen opiniones divergentes sobre cuestiones tales como si Jesús era humano, divino o ambas cosas, y, como mesías, cuál sería su papel en la liberación del pueblo judío de los gobernantes extranjeros o en el…
DNA damage is well recognized as a critical factor in cancer development and progression. DNA lesions create an abnormal nucleotide or nucleotide fragment, causing a break in one or both chains of the DNA strand.
GBM is the most deadly adult brain cancer. The current standard-of-care is surgery followed by RT and temozolomide, which results in a median survival time of only 15 mo. The efficacy of chemotherapies and targeted therapies in GBM is very…
The classic model for neurodegeneration due to mutations in DNA repair genes holds that DNA damage accumulates in the absence of repair, resulting in the death of neurons. This model was originally put forth to explain the dramatic loss of…