Although loss of TAR DNA-binding protein 43 kDa (TDP-43) splicing repression is well documented in postmortem tissues of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), whether this abnormality occurs during early…
Microglial-mediated neuroinflammation plays an important role in vascular dementia, and modulating neuroinflammation has emerged as a promising treatment target. Nicotinamide adenine dinucleotide (NAD+) shows anti-inflammatory and anti…
Sources are the United States Excess Defense Articles (EDA) database, [1 ] Unroca, [2 ] INSS Israel's Middle East Military Balance, [3 ] World Small Arms Inventory, [4 ] Sipri Trade registers [5 ] and the Military Balance in the Middle East…
Fig. 2. FISH analysis of the FRA2A fragile site. FISH analysis of the FRA2A fragile site. A. The BAC-clone 549H5 (labelled green) spans the fragile site FRA2A. B. FISH analysis using the 10 kb L10K (labelled green; chr2: 100721983–100733233…
The diversity of bacterial species in the human oral cavity is well recognized, but a high proportion of them are presently uncultivable. Candidate division TM7 bacteria are almost always detected in metagenomic studies but have not yet…
We tested the hypothesis that Crohn’s disease (CD)-related genetic polymorphisms involved in host innate immunity are associated with shifts in human ileum–associated microbial composition in a cross-sectional analysis of human ileal…
The intestinal epithelium separates us from the microbiota but also interacts with it and thus affects host immune status and physiology. Previous studies investigated microbiota-induced responses in the gut using intact tissues or…