A total of 54 genes were both differentially expressed upon CtrA depletion and bound by CtrA in the ChIP-Seq analysis. These genes represent the experimentally determined direct regulon of S. meliloti CtrA and include genes encoding…
Constitutive YAP1 signaling promotes intrinsic resistance in KRAS;TP53 (KP) mutant lung cancer. Intermittent treatment with the BET inhibitor JQ1 thus overcomes resistance to combined pathway inhibition in KL and KP Gemms.
Prkaa1, which encodes the catalytic subunit of the AMP-activated protein kinase (AMPK), is a notable target of natural selection in Andeans and has been associated with protective fetal phenotypes in this population.