A genome landscape of SRSF3-regulated splicing events and gene…
Alternative RNA splicing is an essential process to yield proteomic diversity in eukaryotic cells, and aberrant splicing is often associated with numerous human diseases and cancers.
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Millet seed oil activates β–catenin signaling and promotes hair…
Alopecia, regardless of gender, exacerbates psychological stress in those affected. The rising prevalence of alopecia has fueled a research interest in preventing hair loss. This study investigates the potential of millet seed oil (MSO) in…
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Genomic aberrations after short-term exposure to colibactin…
Genotoxic colibactin-producing pks+ Escherichia coli induce DNA double-strand breaks, mutations, and promote tumor development in mouse models of colorectal cancer (CRC). Colibactin’s distinct mutational signature is reflected in human CRC…
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mTOR Complex 2 Controls Glycolytic Metabolism in Glioblastoma…
Aerobic glycolysis (Warburg effect) is a core hallmark of cancer, but the molecular mechanisms underlying it remain unclear. Here, we identify an unexpected central role for Mtorc2 in cancer metabolic reprogramming where it controls…
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Foxo transcription factors control regulatory T cell…
Foxo transcription factors integrate extrinsic signals to regulate cell division, differentiation and survival, and specific functions of lymphoid and myeloid cells. Here we showed the absence of Foxo1 severely curtailed the development of…
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The Yeast Forkhead Transcription Factors Fkh1 and Fkh2 Regulate…
Forkhead box O (FOXO) transcription factors have a conserved function in regulating metazoan lifespan. A key function in this process involves the regulation of the cell cycle and stress responses including free radical scavenging.
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