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Lifespan extension induced by germline ablation in C. elegans is regulated by the nuclear hormone receptor NHR-80 in a process that requires the production of oleic acid by activation of the lipid desaturase FAT-6/SCD1.
Dietary carbohydrate type may influence cardiometabolic risk through alterations in the gut microbiome and microbial-derived metabolites, but evidence is limited. We explored the relative effects of an isocaloric exchange of dietary simple…
Prior studies have shown that disruption of mitochondrial electron transport chain (ETC) function in the nematode Caenorhabditis elegans can result in life extension. Counter to these findings, many mutations that disrupt ETC function in…
Lipid signaling is dysregulated in many diseases with vascular pathology, including cancer, diabetic retinopathy, retinopathy of prematurity, and age-related macular degeneration. We have previously demonstrated that diets enriched in ω-3…
The DDR culminates in either transient cell cycle arrest and DNA repair or elimination of damaged cells by apoptosis4,5. Here we show, that the cytokine interleukin (IL-)22 produced by group 3 innate lymphoid cells (ILC3) and γδ T cells is…
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