Melanoma adapts to RAF/MEK inhibitors through FOXD3-mediated…
The mechanisms underlying adaptive resistance of melanoma to targeted therapies remain unclear. By combining ChIP sequencing with microarray-based gene profiling, we determined that ERBB3 is upregulated by FOXD3, a transcription factor that…
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Subsets of exhausted CD8+ T cells differentially mediate tumor…
T cell dysfunction is a hallmark of many cancers, but the basis for T cell dysfunction and the mechanisms by which antibody blockade of the inhibitory receptor PD-1 (anti-PD-1) reinvigorates T cells are not fully understood.
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Ross Hannan | Head of Department | BSc(Hons) PhD | Australian…
Ross Hannan, Head of Department | Cited by 11,788 | of Australian National University, Canberra (ANU) | Read 304 publications | Contact Ross Hannan
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Elizabeth Grimm | Professor Emeritus | Ph.D. | University of…
Elizabeth Grimm, Professor Emeritus | Cited by 22,118 | of University of Texas MD Anderson Cancer Center, Houston (MD Anderson) | Read 390 publications | Contact Elizabeth Grimm
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PCI Express - Wikipedia
Developed and maintained by the PCI-SIG (PCI Special Interest Group), PCIe is commonly used to connect graphics cards, sound cards, Wi-Fi and Ethernet adapters, and storage devices such as solid-state drives and hard disk drives. [3 ]
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Neurotoxic reactive astrocytes are induced by activated…
Reactive astrocytes are strongly induced by central nervous system (CNS) injury and disease but their role is poorly understood. Here we show that A1 reactive astrocytes are induced by classically-activated neuroinflammatory microglia.
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Mitochondrial dysfunction remodels one-carbon metabolism in…
Mitochondrial dysfunction is associated with a spectrum of human disorders, ranging from rare, inborn errors of metabolism to common, age-associated diseases such as neurodegeneration.
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Broadcom Inc. - Wikipedia, la enciclopedia libre
El 7 de enero de 2020, Accenture PLC acordó adquirir la división de servicios de ciberseguridad de 300 personas de Symantec de Broadcom. [47 ] En febrero de 2020, Broadcom anunció el primer dispositivo cliente WiFi 6E del mundo, el BCM4389…
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ATR: An Essential Regulator of Genome Integrity - PMC
Mutations in ATM predispose carriers to cancer and are found in approximately 0.5–1% of the population6, 7. People with mutations in both alleles of ATM suffer from the neurodegenerative and cancer predisposition disorder ataxia…
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DoubleClick - Wikipedia
DoubleClick Inc. was an American advertisement company that developed and provided Internet ad serving services from 1995 until its acquisition by Google in March 2008. DoubleClick offered technology products and services that were sold…
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