Role for β-catenin and HOX transcription factors in…
We used the model nematode Caenorhabditis elegans infected with the human pathogen Staphylococcus aureus to identify components of epithelial immunity. Transcriptional profiling and reverse genetic analysis revealed that mutation of the C.
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Adaptive Prkaa1 variant in Andeans is associated with improved…
AMPK is a universal cellular energy sensor involved in a multitude of physiological processes, including ventilation and the hypoxic ventilatory response (HVR) in animal models.
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Analysis of gene expression and chemoresistance of CD133…
Recently, a small population of cancer stem cells in adult and pediatric brain tumors has been identified. Some evidence has suggested that CD133 is a marker for a subset of leukemia and glioblastoma cancer stem cells.
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The impact of cellular metabolism on chromatin dynamics and…
The substrates used to modify nucleic acids and chromatin are affected by nutrient availability and the activity of metabolic pathways. Thus, cellular metabolism constitutes a fundamental component of chromatin status and thereby of genome…
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Structural Basis of a Histone H3 Lysine 4 Demethyl…
Published in the journal: . PLoS Genet 9(1): e32767. doi:10.1371/journal.pgen.1003239 Category: Research Article doi: https://doi.org/10.1371/journal.pgen.1003239
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Long Noncoding RNA Malat1 Controls Cell Cycle Progression by…
The long noncoding Malat1 RNA is upregulated in cancer tissues and its elevated expression is associated with hyper-proliferation, but the underlying mechanism is poorly understood.
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Nature versus nurture - Wikipedia
The alliterative expression "nature and nurture" in English has been in use since at least the Elizabethan period [1 ] and goes back to medieval French. [2 ] The complementary combination of the two concepts is an ancient concept (Ancient…
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IgE-Mediated Systemic Anaphylaxis And Its Association With Gene…
The most severe anaphylaxes involve angioedema of the airway and severe hypotension with cardiovascular collapse.2–5 The effects of released histamine are central to this, and produce falls in systolic blood pressure and venous return along…
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Developmental Basis of Phallus Reduction during Bird Evolution…
All birds reproduce by internal fertilization, but only ∼3% of birds have retained a phallus capable of intromission. A number of hypotheses have been proposed for the evolutionary mechanisms that drove phallus reduction; however, the…
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Chromosome Conformation Capture
The significance of genome organization for cell identity, gene expression programmes, cancer, and cell division are some of the central topics of inquiry.
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