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Leucine rich repeat kinase 2 (LRRK2) mutations are the most common genetic cause of Parkinson's disease (PD) although LRRK2 function remains unclear. We report a new role for LRRK2 in regulating autophagy and describe the recruitment of…
Mitochondrial reactive oxygen species (mtROS) homeostasis plays an essential role in preventing oxidative injury in endothelial cells, an initial step in atherogenesis. Resveratrol (RSV) possesses a variety of cardioprotective activities…
From cDNA, atfs-1 was amplified with the following Gateway cloning primers using the New England Biolabs High-Fidelity Phusion DNA polymerase PCR kit: ATTB1 ATFS-1: ; ATTB2 ATFS1: .
A Coxiella-type microbe occurs at 100% frequency in all Amblyomma americanum ticks thus far tested. Using laboratory-reared ticks free of other microbes, we identified the Amblyomma-associated Coxiella microbe in several types of tissue and…
Thus SwrB presents a novel mechanism to supervise an early structural checkpoint regulating machine assembly. Targeting functional regulators like SwrB could inhibit T3SS-based strategies of pathogens.