YAP and TAZ, the ultimate targets of the Hippo signaling pathway, are transcriptional co-activators of AP-1 proteins and STAT3 through which they are important for breast cellular transformation.
Prior to ligand activation, the unactivated aryl hydrocarbon receptor (AhR) exists in a heterotetrameric 9S core complex consisting of the AhR ligand-binding subunit, a dimer of hsp90, and an unknown subunit.
It belongs to the phylum Apicomplexa, which includes Plasmodium falciparum, the most lethal form of malaria parasites [1]. T. gondii is the most common cause of congenital neurological defects in humans, and an agent for devastating…
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This is a physiological adaptation to allow the heart to pump enough blood to perfuse the organs. Eventually the heart grows so large it is not able to pump blood efficiently.