Melanoma adapts to RAF/MEK inhibitors through FOXD3-mediated…
The mechanisms underlying adaptive resistance of melanoma to targeted therapies remain unclear. By combining ChIP sequencing with microarray-based gene profiling, we determined that ERBB3 is upregulated by FOXD3, a transcription factor that…
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Intermittent fasting confers protection in CNS autoimmunity by…
Multiple sclerosis (MS) is a central nervous system (CNS) inflammatory demyelinating disease impacted by the interplay of genetic and environmental factors. It is presumed to be autoimmune.
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HDAC5-LSD1 Axis Regulates Antineoplastic Effect of Natural HDAC…
Our recent studies have shown that crosstalk between histone deacetylase 5 (HDAC5) and lysine-specific demethylase 1 (LSD1) facilitates breast cancer progression. In this work, we demonstrated that regulatory activity at −356 to −100 bp…
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Parkinson-Associated SNCA Enhancer Variants Revealed by Open…
Additional genotyping across the SNCA locus identified a single PD-associated haplotype, containing the minor alleles of both of the aforementioned PD-risk variants.
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High IGF-IR activity in triple-negative breast cancer cell…
We previously reported an IGF gene expression signature, based upon genes induced or repressed by IGF-I, which correlated with poor prognosis in breast cancer. We tested if the IGF signature was affected by anti-IGF-IR inhibitors, and if…
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Mistletoe lectin inhibits growth of Myc‐amplified small‐cell…
Small‐cell lung cancer (SCLC) is the deadliest form of lung cancer but lacks targeted therapies. We studied the effect of the natural product mistletoe lectin (ML) in pre‐clinical models of SCLC, focusing on cell lines with amplification of…
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Official journal of the American College of Gastroenterology…
Chronic pancreatitis (CP) is historically defined as an irreversible inflammatory condition of the p
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Genetic vulnerability and adverse mental health outcomes…
Models 1–3 assess the associations with PTSD and Models 4–6 with depression following TBI.
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Combined Intermittent & Sustained Hypoxia & High-Fat Diet | NSS
Interactive effect of a combination of intermittent hypoxia & sustained hypoxia & high fat diet on proximal colonic microbiota & colonic gene expression pattern
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