Oxidative stress and metabolic dysregulation of the RPE have been implicated in AMD; however, the molecular regulation of RPE metabolism remains unclear. The transcriptional coactivator, peroxisome proliferator-activated receptor-gamma…
Mitochondrial dysfunction and oxidative stress are critical factors in the pathogenesis of age-dependent neurodegenerative diseases. PGC-1α, a master regulator of mitochondrial biogenesis and cellular antioxidant defense, has emerged as a…
I serve as the Director for the Montana Center of Work Physiology and Exercise Metabolism. Our work focuses on the unique physiology of humans as they interact with a wide range of austere environments.
Exercise-induced increase in peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) expression has been shown to increase the expression of the fibronectin type III domain containing 5 (FNDC5) gene and thereby its product…
Published in the journal: . PLoS Genet 10(10): e32767. doi:10.1371/journal.pgen.1004696 Category: Research Article doi: https://doi.org/10.1371/journal.pgen.1004696