Oxidative stress and metabolic dysregulation of the RPE have been implicated in AMD; however, the molecular regulation of RPE metabolism remains unclear. The transcriptional coactivator, peroxisome proliferator-activated receptor-gamma…
Mitochondrial dysfunction and oxidative stress are critical factors in the pathogenesis of age-dependent neurodegenerative diseases. PGC-1α, a master regulator of mitochondrial biogenesis and cellular antioxidant defense, has emerged as a…
I serve as the Director for the Montana Center of Work Physiology and Exercise Metabolism. Our work focuses on the unique physiology of humans as they interact with a wide range of austere environments.
Exercise-induced increase in peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) expression has been shown to increase the expression of the fibronectin type III domain containing 5 (FNDC5) gene and thereby its product…
Published in the journal: . PLoS Genet 10(10): e32767. doi:10.1371/journal.pgen.1004696 Category: Research Article doi: https://doi.org/10.1371/journal.pgen.1004696
While intermittent hypoxic training (IHT) has been reported to evoke cellular responses via hypoxia inducible factors (HIFs) but without substantial performance benefits in endurance athletes, we hypothesized that repeated sprint training…