Selected Publications | National Institute of Environmental…

These grants mostly support research studies, but also cooperative research and development projects.
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Epigenomic Profiling of Human CD4+ T Cells Supports a Linear…

We generated deep epigenomes comprising genome-wide profiles of DNA methylation, histone modifications, DNA accessibility, and coding and non-coding RNA expression in naive, central-, effector-, and terminally differentiated CD45RA+ CD4
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A Draft Sequence of the Neandertal Genome - PMC

Neandertals, the closest evolutionary relatives of present-day humans, lived in large parts of Europe and western Asia before disappearing 30,000 years ago. We present a draft sequence of the Neandertal genome composed of more than 4
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How to Reduce Purchasing Cycle Time and Costs

Learn some of the best practices for improving your purchasing process efficiency and effectiveness by reducing purchasing cycle time and costs.
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IL-17 Induces an Expanded Range of Downstream Genes in…

IL-17 is the defining cytokine of the Th17, Tc17, and γδ T cell populations that plays a critical role in mediating inflammation and autoimmunity. Psoriasis vulgaris is an inflammatory skin disease mediated by Th1 and Th17 cytokines with…
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Alström Syndrome: Genetics and Clinical Overview - PMC

Alström syndrome is a rare autosomal recessive genetic disorder characterized by cone-rod dystrophy, hearing loss, childhood truncal obesity, insulin resistance and hyperinsulinemia, type 2 diabetes, hypertriglyceridemia, short stature in…
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Aging-dependent demethylation of regulatory elements correlates…

Aging is driven by changes of the epigenetic state that are only partially understood. We performed a comprehensive epigenomic analysis of the pancreatic β cell, key player in glucose homeostasis, in adolescent and very old mice.
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SPAK Isoforms and OSR1 Regulate Sodium-Chloride Co-transporters…

Background: Full-length SPAK is thought to be necessary and sufficient to activate NCC in the distal convoluted tubule (DCT). Results: SPAK knock-out disrupts a signaling network, involving OSR1, in the DCT but not the TAL, preventing NCC…
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Encodes a Highly Conserved Protein Important to Ne…

Published in the journal: . PLoS Genet 11(7): e32767. doi:10.1371/journal.pgen.1005344 Category: Research Article doi: https://doi.org/10.1371/journal.pgen.1005344
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