The cannabinoid receptor 1 (CB1) is the principal target of the psychoactive constituent of marijuana, the partial agonist Δ9-tetrahydrocannabinol (Δ9-THC)1. Here we report two agonist-bound crystal structures of human CB1 in complex with a…
The existence and maintenance of biological rhythms linked to the 24-h light-dark cycle are essential to the health and functioning of an organism. Although much is known concerning central clock mechanisms, much less is known about control…
The α4β7 integrin promotes homing of T cells to intestinal sites. The α4 integrin subunit that pairs with β7 integrin can also pair with β1 integrin. Here, we show that the preferential pairing of β1 integrin with α4 integrin regulates the…
Animal models of infection have provided valuable insight into diverse mechanisms of bacterial pathogenesis. Application of microarray technology to these models has further enabled analysis of bacterial global gene expression during…