Genetic screens help infer gene function in mammalian cells, but it has remained difficult to assay complex phenotypes – such as transcriptional profiles – at scale. Here, we develop Perturb-seq, combining single cell RNA-seq and Crispr…
As a national gendarmerie, it is military in nature and is responsible for civil policing under the authority of both the Ministry of the Interior and the Ministry of Defence. [2 ] [3 ] The role of the Ministry of Defence is limited except…
Mutations in genes encoding ribosomal proteins cause the Minute phenotype in Drosophila and mice, and Diamond-Blackfan syndrome in humans. Here we report two mouse dark skin (Dsk) loci caused by mutations in Rps19 (ribosomal protein S19…
Circadian rhythms of cell and organismal physiology are controlled by an autoregulatory transcription-translation feedback loop that regulates the expression of rhythmic genes in a tissue-specific manner.
A system for performing multi-dimensional quantum search, quantum computation, quantum memory, quantum storage, and quantum retrieval includes a structure and method for: enabling components and systems for quantum search, and more…
Methicillin-resistant Staphylococcus aureus (MRSA) is an important pathogen. Its resistance to multiple antibiotics and its prevalence in healthcare establishments make it a serious threat to human health that requires novel interventions.