The Novel Tail-anchored Membrane Protein Mff Controls…
Few components of the mitochondrial fission machinery are known, even though mitochondrial fission is a complex process of vital importance for cell growth and survival. Here, we describe a novel protein that controls mitochondrial fission…
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Activation of the Innate Signaling Molecule MAVS by Bunyavirus…
La Crosse virus (LACV), a zoonotic Bunyavirus, is a major cause of pediatric viral encephalitis in the United States. A hallmark of neurological diseases caused by LACV and other encephalitic viruses is the induction of neuronal cell death…
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Role of Mitochondrial Remodeling in Programmed Cell Death in…
The role of mitochondria in Drosophila programmed cell death remains unclear, although certain gene products that regulate cell death seem to be evolutionarily conserved. We find that developmental programmed cell death stimuli in vivo and…
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Mff is an essential factor for mitochondrial recruitment of Drp…
Localization of the dynamin-related GTPase Drp1 to mitochondria relies on the mitochondrial fission factor Mff.
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Oncogenic PKA signaling increases c-MYC protein expression…
Protein kinase A-driven increases in c-MYC protein expression and tumor cell proliferation can be blocked by eIF4A inhibitors, suggesting a potential new treatment option for patients with oncogenic PKA activation.
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Interleukin-22 protects intestinal stem cells against genotoxic…
The DDR culminates in either transient cell cycle arrest and DNA repair or elimination of damaged cells by apoptosis4,5. Here we show, that the cytokine interleukin (IL-)22 produced by group 3 innate lymphoid cells (ILC3) and γδ T cells is…
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The experimental chemotherapeutic N6-furfuryladenosine (kinetin…
Cytokinins and cytokinin nucleosides are purine derivatives with potential anticancer activity. N6-furfuryladenosine (FAdo, kinetin-riboside) displays antiproliferative and apoptogenic activity against various human cancer cell lines, and…
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Am J Cancer Res 2020;10(9):2813-2831
Sciences, No. 19A Yuquan Road, Beijing 100049, P. R. China; 3Open Studio for Drugability Research of Marine
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Bach2 Promotes B Cell Receptor–Induced Proliferation of B…
Yuichi Miura, Mizuho Morooka, Nicolas Sax, Rahul Roychoudhuri, Ari Itoh-Nakadai, Andrey Brydun, Ryo
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