Loss- or Gain-of-Function Mutations in ACOX1 Cause Axonal Loss…
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Hydroxytyrosol Modulates Adipocyte Gene and miRNA Expression…
Chronic inflammation of the adipose tissue (AT) is a major contributor to obesity-associated cardiometabolic complications. The olive oil polyphenol hydroxytyrosol (HT) contributes to Mediterranean diet cardiometabolic benefits through…
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Foxp3 reprograms T cell metabolism to function in low glucose…
Immune cells function in diverse metabolic environments. Tissues with low glucose and high lactate concentrations, such as the intestinal tract or ischemic tissues, frequently require immune responses to be more pro-tolerant avoiding…
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T cell receptor signaling controls Foxp3 expression via PI3K…
Regulatory T (Treg) cells safeguard against autoimmunity and immune pathology. Because determinants of the Treg cell fate are not completely understood, we have delineated signaling events that control the de novo expression of Foxp3 in…
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Yersinia pestis insecticidal-like toxin complex (Tc) family…
Toxin complex (Tc) family proteins were first identified as insecticidal toxins in Photorhabdus luminescens and have since been found in a wide range of bacteria. The genome of Yersinia pestis, the causative agent of bubonic plague…
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Oncogenic PKA signaling increases c-MYC protein expression…
Protein kinase A-driven increases in c-MYC protein expression and tumor cell proliferation can be blocked by eIF4A inhibitors, suggesting a potential new treatment option for patients with oncogenic PKA activation.
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Gene editing to prevent ventricular arrhythmias associated with…
Abolishing depolarization-associated genes HCN4, Cacna1H, and SLC8A1, along with overexpressing hyperpolarization-associated KCNJ2, creates hPSC-CMs that lack automaticity but contract when externally stimulated.
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Cish actively silences TCR signaling in CD8+ T cells to…
Palmer et al. find that Cish, a member of the SOCS family, is induced by TCR stimulation in CD8+ T cells and inhibits their functional avidity against tumo
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