CTCF binds the proximal exonic region of Htert and inhibits its…

The expression of the catalytic subunit (Htert) represents the limiting factor for telomerase activity. Previously, we detected a transcriptional repressor effect of the proximal exonic region (first two exons) of the Htert gene.
Neobsahuje kelbmthMusí obsahovat kelbmth

Genome-Wide and Phase-Specific DNA-Binding Rhythms of BMAL1

Temporal mapping during a circadian day of binding sites for the BMAL1 transcription factor in mouse liver reveals genome-wide daily rhythms in DNA binding and uncovers output functions that are controlled by the circadian oscillator.
Neobsahuje kelbmthMusí obsahovat kelbmth

Site Map - January 19, 1958 - The New York Times

London Police Put Down Piccadilly Circus Rioting
Neobsahuje kelbmthMusí obsahovat kelbmth

Dual role of DNA methylation inside and outside of CTCF-binding…

Expression of Htert is the major limiting factor for telomerase activity. We previously showed that methylation of the Htert promoter is necessary for its transcription and that CTCF can repress Htert transcription by binding to the first…
Neobsahuje kelbmthMusí obsahovat kelbmth

Coordination of Cell Proliferation and Cell Fate D

Published in the journal: . PLoS Genet 9(10): e32767. doi:10.1371/journal.pgen.1003884 Category: Research Article doi: https://doi.org/10.1371/journal.pgen.1003884
Neobsahuje kelbmthMusí obsahovat kelbmth

Transcriptional Profiling of mRNA Expression in the Mouse…

Intestinal epithelial cells and the myenteric plexus of the mouse gastrointestinal tract contain a circadian clock–based intrinsic timekeeping system. Because disruption of the biological clock has been associated with increased…
Neobsahuje kelbmthMusí obsahovat kelbmth

Targeting the MYC oncogene with a selective bi-steric Mtorc1

The Mtorc1 complex regulates MYC translation through 4EBP1 and S6K. However, agents that selectively target Mtorc1 (without affecting Mtorc2) have so far failed to reactivate 4EBP1 and, thus, cannot effectively suppress MYC in vivo.
Neobsahuje kelbmthMusí obsahovat kelbmth

Cellular and developmental control of O2 homeostasis by hypoxia…

Hypoxia is an essential developmental and physiological stimulus that plays a key role in the pathophysiology of cancer, heart attack, stroke, and other major causes of mortality. Hypoxia-inducible factor 1 (HIF-1) is the only known…
Neobsahuje kelbmthMusí obsahovat kelbmth

Univerzita Karlova

Ač je druh v bakteriologii základní taxonomická jednotka, jeho pojetí (species concept) i způ- sob rozlišení (species definition) jsou předmětem neustávající diskuse.
Neobsahuje kelbmthMusí obsahovat kelbmth
Při pokusu o sdílení polohy došlo k chybě
Více informací
odkazuje na služby nejen od Seznam.cz.

© 1996–2025 Seznam.cz, a.s.