The expression of the catalytic subunit (Htert) represents the limiting factor for telomerase activity. Previously, we detected a transcriptional repressor effect of the proximal exonic region (first two exons) of the Htert gene.
Temporal mapping during a circadian day of binding sites for the BMAL1 transcription factor in mouse liver reveals genome-wide daily rhythms in DNA binding and uncovers output functions that are controlled by the circadian oscillator.
Expression of Htert is the major limiting factor for telomerase activity. We previously showed that methylation of the Htert promoter is necessary for its transcription and that CTCF can repress Htert transcription by binding to the first…
Published in the journal: . PLoS Genet 9(10): e32767. doi:10.1371/journal.pgen.1003884 Category: Research Article doi: https://doi.org/10.1371/journal.pgen.1003884
Ambos también marcaron el primer lanzamiento de Maverick, su propia compañía de entretenimiento multimedia, que consistía en una productora de cine y una discográfica.
Intestinal epithelial cells and the myenteric plexus of the mouse gastrointestinal tract contain a circadian clock–based intrinsic timekeeping system. Because disruption of the biological clock has been associated with increased…
The Mtorc1 complex regulates MYC translation through 4EBP1 and S6K. However, agents that selectively target Mtorc1 (without affecting Mtorc2) have so far failed to reactivate 4EBP1 and, thus, cannot effectively suppress MYC in vivo.
Hypoxia is an essential developmental and physiological stimulus that plays a key role in the pathophysiology of cancer, heart attack, stroke, and other major causes of mortality. Hypoxia-inducible factor 1 (HIF-1) is the only known…
Ač je druh v bakteriologii základní taxonomická jednotka, jeho pojetí (species concept) i způ- sob rozlišení (species definition) jsou předmětem neustávající diskuse.