MATE transport of the E. coli-derived genotoxin colibactin…
Various forms of cancer have been linked to the carcinogenic activities of microorganisms1–3. The virulent gene island polyketide synthase (pks) produces the secondary metabolite colibactin, a genotoxic molecule(s) causing double-stranded…
The RNA ligands for mouse proline-rich RNA-binding protein…
Mouse proline-rich RNA-binding protein (mPrrp) is a mouse ortholog of Xenopus Prrp, which binds to a vegetal localization element (VLE) in the 3′-untranslated region (3′-UTR) of Vg1 mRNA and is expected to be involved in the transport and…
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SARS-CoV-2 spike L452R variant evades cellular immunity and…
Many SARS-CoV-2 variants with naturally acquired mutations have emerged. These mutations can affect viral properties such as infectivity and immune resistance. Although the sensitivity of naturally occurring SARS-CoV-2 variants to humoral…
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(PDF) The Upper Guinea origins of Papiamentu Linguistic and…
This paper deals with the linguistic and historical relationships between Papiamentu and Upper Guinea Creole as spoken on the Santiago island of Cape Verde and in Guinea-Bissau and Casamance.
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Nonvirally Modified Autologous Primary Hepatocytes Correct…
Current gene- and cell-based therapies have significant limitations which impede widespread clinical application. Taking diabetes mellitus as a paradigm, we have sought to overcome these limitations by ex vivo electrotransfer of a nonviral…
A Novel Human Cytomegalovirus Locus Modulates Cell…
We previously determined that pUL138 localized to the Golgi apparatus during infection or transient expression [19]. To determine the subcellular localization of pUL133, pUL135, and pUL136, we infected MRC5 fibroblasts with FIX-UL133myc…
Structural basis of homo- and heterotrimerization of collagen I…
Fibrillar collagen molecules are synthesized as precursors, procollagens, with large propeptide extensions. While a homotrimeric form (three α1 chains) has been reported in embryonic tissues as well as in diseases (cancer, fibrosis, genetic…
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Manipulating condensation of thermo-sensitive SUF4 protein…
We show that at warm temperatures (20°C), SUF4 forms nuclear condensates that co-localize with key flowering regulators (Frigida and Early Flowering 7 [ELF7]), whereas at 4°C, these condensates disperse into the nucleoplasm.
Acts as a Tumor Suppressor in a Murine Retinoblast…
Published in the journal: . PLoS Genet 6(4): e32767. doi:10.1371/journal.pgen.1000923 Category: Research Article doi: https://doi.org/10.1371/journal.pgen.1000923
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The Tumor Suppressor BCL7B Functions in the Wn…
Downregulation of WRM-1, a homolog of ß-catenin [40]–[42], suppressed both seam cell reduction and Ste phenotypes. Although LSY-22 is considered a homolog of Groucho-like protein [43] and is also a member of the noncanonical Wnt pathway, lsy…
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