Stable nuclear expression of ATP8 and ATP6 genes rescues a…
Tests for ATP hydrolysis / synthesis, oxygen consumption, glycolytic metabolism and viability all indicate a significant functional rescue of the mutant phenotype (including re-assembly of Complex V) following stable co-expression of ATP8…
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A fluid biomarker reveals loss of TDP-43 splicing repression in…
Although loss of TAR DNA-binding protein 43 kDa (TDP-43) splicing repression is well documented in postmortem tissues of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), whether this abnormality occurs during early…
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Ching-Feng Cheng | Professor and Vice Superintendent | Doctor…
Ching-Feng Cheng, Professor and Vice Superintendent | Cited by 4,973 | | Read 157 publications | Contact Ching-Feng Cheng
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The atlA Operon of Streptococcus mutans: Role in Autolysin…
The Smu0630 protein (AtlA) was recently shown to be involved in cell separation, biofilm formation, and autolysis. Here, transcriptional studies revealed that atlA is part of a multigene operon under the control of at least three promoters…
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Ror2 Enhances Polarity and Directional Migration o…
Published in the journal: . PLoS Genet 7(12): e32767. doi:10.1371/journal.pgen.1002428 Category: Research Article doi: https://doi.org/10.1371/journal.pgen.1002428
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High expression of oleoyl-ACP hydrolase underpins life…
High OLAH levels were also detected in patients hospitalized with life-threatening seasonal influenza, Covid-19, respiratory syncytial virus (RSV), and multisystem inflammatory syndrome in children (MIS-C) but not during mild disease.
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Experimentally Determined Evolutionary Model Dramatically…
Abstract. All modern approaches to molecular phylogenetics require a quantitative model for how genes evolve. Unfortunately, existing evolutionary models d
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Abnormal development of the cerebral cortex and cerebellum in…
Nuclear lamins are components of the nuclear lamina, a structural scaffolding for the cell nucleus. Defects in lamins A and C cause an array of human diseases, including muscular dystrophy, lipodystrophy, and progeria, but no diseases have…
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Mitochondrial Ubiquitin Ligase March5 Promotes TLR…
To address the mechanism of March5 action, we explored whether March5 could interact with TLR signaling proteins. A co-immunoprecipitation assay revealed that March5 interacted with TRAF6, TANK and MAVS but did not interact with TRAF3, NEMO…
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TopBP1 Governs Hematopoietic Stem/Progenitor C…
Except WT and cas003-NLS, all TopBP1 mutation forms are unable to rescue hematopoietic defects in topbp1cas003 mutants.
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