There is massive destruction of transcripts during the maturation of mouse oocytes. The objective of this project was to identify and characterize the transcripts that are degraded versus those that are stable during the transcriptionally…
Analysis of RNAi components, including AltE identification, was performed using publicly available deep sequencing data from mouse GV oocytes (Smallwood et al., 2011; http://sra.dnanexus.com/runs/ERR034797).
The pre- and post-division migrations are dependent on microtubules and actin, respectively, and the polarity crescent is the unifying landmark that is both necessary and sufficient to orient both nuclear migrations.
Sirtuins have been widely reported to be involved in multiple biological processes; however, their function in oocyte meiosis has not been. Here, by confocal scanning and quantitative analysis, we show that specific depletion of Sirt2 in…
Lymphoid specific helicase (Lsh) belongs to the family of SNF2/helicases. Disruption of Lsh leads to developmental growth retardation and premature aging in mice. However, the specific effect of Lsh on human cellular senescence remains…
Dr B Parameswari works as Senior Scientist, ICAR-Nbpgr Regional Station, Hyderabad, India. Her broad research areas include diagnostics, genomics and management of plant viruses. To undertake plant quarantine over the germplasm exchange…
Celiac Disease (CD) is an autoimmune disorder of the small intestine in which dietary gluten ingestion leads to a chronic enteropathy. Recently, scientific evidence suggested a potential role of gut microbiota in CD.
The suc5 mutation dramatically reduced the extensive cell death observed in chs3-1 mutants grown at 16°C (Fig 1B). Furthermore, the accumulation of hydrogen peroxide (H2O2) in chs3 suc5 plants grown at 16°C was dramatically reduced compared…