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Extensive biochemical characterization of cells in the inner ear has been hampered by a lack of tools with which to identify inner-ear proteins. By using a single-chain antibody fragment isolated from a bacteriophage-displayed library, we…
Published in the journal: . PLoS Pathog 10(4): e32767. doi:10.1371/journal.ppat.1004074 Category: Research Article doi: https://doi.org/10.1371/journal.ppat.1004074
Little is known about miRNA decay. A target-directed miRNA degradation mechanism (TDMD) has been suggested, but further investigation on endogenous targets is necessary. Here, we identify hundreds of targets eligible for TDMD and show that…
In mammals, caloric restriction consistently results in extended lifespan. Epigenetic information encoded by DNA methylation is tightly regulated, but shows a striking drift associated with age that includes both gains and losses of DNA…
The Arabidopsis N6-methyladenosine (m6A)-binding protein ECT2 binds to m6A in the canonical RR[m6A]CH motif, not a plant-specific motif as previously thought, and its intrinsically disordered region contributes to mRNA binding via contacts…
English: Nikoloz Chkheidze or Nikolay Semyonovich Chkheidze, commonly known as Karlo Chkheidze (1864-1926) was a Georgian Menshevik politician who helped to introduce Marxism to Georgia in the 1890s and played a prominent role in the…
Published in the journal: . PLoS Genet 11(6): e32767. doi:10.1371/journal.pgen.1005047 Category: Research Article doi: https://doi.org/10.1371/journal.pgen.1005047
The constitutive androstane receptor (CAR) plays a key role in the control of drug metabolism and transport by mediating the phenobarbital-type induction of many phase I and II drug metabolizing enzymes and drug transporters.