Limita al nordeste con la región francesa de Nueva Aquitania (departamento de Pirineos Atlánticos, que incluye el País Vasco francés), al noroeste con el País Vasco (provincias de Álava y Guipúzcoa), al este y sureste con Aragón (provincias…
Activation of colonic proteinase-activated receptor-2 (PAR2) caused inflammation and increased mucosal permeability in mouse colon. The present study was aimed at characterizing the possible links between these two phenomena.
Alessandra Aguiar currently works at the Fiocruz Paraná - Instituto Carlos Chagas (ICC), Fundação Oswaldo Cruz. Their current project is 'Cytotoxicity'.
The resulting vector, pTS4-RON5-DHFR, was linearized with ApaI and transfected into RON5-3xMYC or RON5-3xHA parasites. Following selection with 1 µM pyrimethamine, parasites were cloned by limiting dilution and genomic DNA from individual…
Toll-like receptor 5 (TLR5) recognition of flagellin instigates inflammatory signalling. Significant sequence variation in TLR5 exists between animal species but its impact on activity is less well understood.
Anaphylatoxins C3a and C5a are important modulators for dendritic cell activation and function in mice. In order to verify the significance of these observations in man, we have investigated the functional modulation of human monocytes…
To address the mechanism of March5 action, we explored whether March5 could interact with TLR signaling proteins. A co-immunoprecipitation assay revealed that March5 interacted with TRAF6, TANK and MAVS but did not interact with TRAF3, NEMO…