DNA methylation at the 5-position of cytosine (5-mC) is a key epigenetic mark critical for various biological and pathological processes. 5-mC can be converted to 5-hydroxymethylcytosine (5-hmC) by the Ten-Eleven Translocation (TET) family…
The side effects of systemic chemotherapy used to treat cancer are often severe. For decades, oncologists have focused on treating the tumor, which may result in damage to the tumor-bearing host and its immune system.
To initiate an adaptive immune response, rare antigen-specific naïve CD4+ T cells must interact with equally rare dendritic cells (DCs) bearing cognate peptide-MHC complexes. Lymph nodes (LN) draining the site of antigen entry are populated…
Hepatitis C virus (HCV) infection causes acute and often also chronic liver disease. Worldwide, prevalence of infection is estimated to exceed that of human immunodeficiency virus infection fourfold.
Anil K Kashyap, CBE (born 1960) is the Stevens Distinguished Service Professor of Economics and Finance [1 ] at the University of Chicago's Booth School of Business.
Oncogenic BRAF causes genome duplication and reversible growth arrest in human melanocytes that is conditional on microRNA expression and differentiation state.
Malignant melanomas do not uniformly retain expression of melanocytic gene products—an observation associated with diagnostic dilemmas. Microphthalmia transcription factor (Mitf) is a melanocytic nuclear protein critical for the embryonic…