Ronald Swanstrom | Cited by 15,331 | of University of North Carolina at Chapel Hill, Chapel Hill (UNC) | Read 356 publications | Contact Ronald Swanstrom
Lentivirus vectors based on human immunodeficiency virus (HIV) type 1 (HIV-1) constitute a recent development in the field of gene therapy. A key property of HIV-1-derived vectors is their ability to infect nondividing cells.
Results demonstrate that Crispr/Cas9-mediated target gene activation can be achieved in vivo, leading to measurable phenotypes and amelioration of disease symptoms.
Roy Steigbigel, Distinguished Service Professor | Cited by 7,712 | of Stony Brook University, Stony Brook (Stony Brook) | Read 120 publications | Contact Roy Steigbigel
Extremely early antiretroviral therapy during HIV-1 subtype C infection leads to faster decline in genome-intact viruses, reduced genetic complexity, and immune escape, and may enhance reservoir clearance with additional interventional…
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and dioxin-like compounds are widely encountered toxic substances suspected of interfering with the endocrine systems of humans and wildlife, and of contributing to the loss of fertility.