Our goal was to gain a better understanding of the inflammatory pathways affected during localized vulvodynia, a poorly understood, common, and debilitating condition characterized by chronic pain of the vulvar vestibule.
P300 and CBP (CREB Binding Protein) are transcriptional co-activators that regulate gene expression through acetylation of histones and chromatin remodeling. p300 interacts with over 50 intracellular proteins affecting a range of signaling…
This comprehensive article covers the history of epigenetics, discusses the factors that play a role in this process, and highlights which areas of biology are influenced by epigenetic mechanisms.