When autophagy is induced, ULK1 phosphorylates Ambra1, releasing the autophagy core complex from the cytoskeleton and allowing its relocalization to the ER membrane to nucleate autophagosome formation.
Es un proceso de división celular en la que una célula diploide (2n) experimenta dos divisiones sucesivas, con la capacidad de generar cuatro células haploides (n). En los organismos con reproducción sexual tiene importancia, ya que es el…
De hecho, la célula es el elemento de menor tamaño que puede considerarse vivo. [2 ] De este modo, puede clasificarse a los organismos vivos según el número de células que posean: si solo tienen una, se les denomina unicelulares (como…
Though the fossil record is incomplete, numerous studies have demonstrated that there is enough information available to give a good understanding of the pattern of diversification of life on Earth. [2 ] [3 ] [4 ] In addition, the record…
Although epidemiological data have indicated that a strong negative association exists between coffee consumption and the prevalence of obesity-associated diseases, the molecular mechanisms by which coffee intake prevents obesity-associated…
Throughout life, adult organs continually adapt to variable environmental factors. Adaptive mechanisms must fundamentally differ from homeostatic maintenance, but little is known about how physiological factors elicit tissue remodeling.
Morpholino oligonucleotides are the most common anti-sense “knockdown” technique used in zebrafish (Danio rerio). This review discusses common practices for the design, preparation, and deployment of morpholinos in this vertebrate model…
J. Alberto Aragon-Correa (also known as Alberto Aragon and Juan Alberto Aragón Correa) is a business data scientist and the current Professor of Management and Director of the Talent Incubator at the University of Granada. [1 ] Aragon…