Mitochondria—classically viewed as the powerhouses of the cell—have taken center stage in disease pathogenesis and resolution. Mitochondrial dysfunction, which originates from primary defects within the organelle or is induced by…
For instance, T548 (D4) is far away from the mapped epitope residues (D1 and D2) and therefore cannot directly affect BC8 or HI30 binding (Fig. 1b). Furthermore, Y232 is buried in the protein with only 4% surface accessibility (Extended…
Explora cómo la inmunoterapia, incluyendo células CAR-T y anticuerpos monoclonales, ofrece nuevas esperanzas en el tratamiento de la leucemia linfocítica aguda, enfrentando desafíos actuales.
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Cysteinyl leukotrienes(CysLT), leukotrienes C4, D4, and E4 (LTC4, LTD4, LTE4) are secreted generally by eosinophils, mast cells, monocytes and macrophages, plus they exert a number of activities which emphasize their importance as…
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