CDC42 Activity Regulates Hematopoietic STEM CELL Aging AND…
The functional decline in hematopoietic function seen during aging involves a progressive reduction in the immune response and an increased incidence of myeloid malignancy, and has been linked to aging of hematopoietic stem cells (HSCs).
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PD-L1 regulates the development, maintenance, and function of…
Both the programmed death (PD) 1–PD-ligand (PD-L) pathway and regulatory T (T reg) cells are instrumental to the maintenance of peripheral tolerance. We demonstrate that PD-L1 has a pivotal role in regulating induced T reg (iT reg) cell…
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Mouse TU tagging: a chemical/genetic intersectional method for…
In this Methodology article, Doe and colleagues describe a new method of covalently labeling and purifying cell type-specific nascent RNA from within their native tissues. Using a Cre-inducible UPRT enzyme, which drives 4TU incorporation…
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Registr_smluv_smlouva_13509.xml
1313313509https://smlouvy.gov.cz/smlouva/135092016-07-19T10:39:24 02:00fk8xqiaMSK registr smluv (Moravskoslezský kraj)7089069228. října 2771/117, 70200 Ostrava, CZOdbor právní a organizační16pziw44Ing.
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Clonal hematopoiesis driven by mutated DNMT3A promotes…
To model DNMT3A-driven CHIP, we used mice with the heterozygous loss-of-function mutation R878H, equivalent to the human hotspot mutation R882H. Partial transplantation with Dnmt3aR878H/+ bone marrow (BM) cells resulted in clonal expansion…
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Increased hematopoietic stem cell mobilization in aged mice…
Hematopoietic stem and progenitor cells (Hspcs) are located in the bone marrow in close association with a highly organized 3-dimensional structure formed by stroma cells, referred to as the niche.
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Control of Foxp3 stability through modulation of TET activity…
TET2 and TET3 redundantly regulate Foxp3 stability, and their activity can be modulated by vitamin C.
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Hepcidin-Mediated Hypoferremia Disrupts Immune Responses to…
Frost et al demonstrate that low concentrations of iron in serum, caused by the hormone hepcidin, inhibit the body’s response to vaccines and infections; conversely, increasing iron can boost immunity.
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hadromat.eu/sitemap-cpmqnrpot.txt
Https://hadromat.eu/259xhkn68b5swv0q05rs.html https://hadromat.eu/m3nm8/6932603.html https://hadromat.eu/i5gqj/seutt5y1i9rp.html https://hadromat.eu/ 304 https://hadromat.eu/h79xj/of2pzn4g7r9hxw.html https://hadromat.eu/6rrnn/3170662.html…
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RAG suppresses group 2 innate lymphoid cells | eLife
Developmental imprinting controls innate type 2 immune function and allergic inflammation.
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