Lentivirus vectors based on human immunodeficiency virus (HIV) type 1 (HIV-1) constitute a recent development in the field of gene therapy. A key property of HIV-1-derived vectors is their ability to infect nondividing cells.
The human Samhd1 protein potently restricts lentiviral infection in dendritic cells and monocyte/macrophages, but is antagonized by the primate lentiviral protein Vpx which targets Samhd1for degradation.
Computational science, also known as scientific computing, technical computing or scientific computation (SC), is a division of science, and more specifically the Computer Sciences, which uses advanced computing capabilities to understand…
The genome is about 9.3 kb (one monomer) (Figure 1. Lentivirus). In addition to the structural gag, pro, pol and env genes, there are additional genes, depending on the virus (e.g. for HIV-1: vif, vpr, vpu, tat, rev and nef) whose products…
They met regularly every 4–6 weeks from early 1982 to 1985. With help from the Centers of Disease Control, this group formed the hypothesis that AIDS was caused by a human retrovirus similar to HTLV.
The interferon-inducible membrane protein tetherin (Bst-2, or CD317) is an antiviral factor that inhibits enveloped virus release by cross-linking newly formed virus particles to the producing cell.