Andrew Lackner, Professor of Microbiology, Immunology and Pathology | Cited by 29,314 | of Tulane University, New Orleans (TU) | Read 378 publications | Contact Andrew Lackner
At the forefront of nanotechnology R&D, my work revolutionises materials application in… · Experience: Hanano Materials technology · Education: University of Bath · Location: Godmanchester · 500+ connections on LinkedIn.
Class switch recombination (CSR) is a DNA recombination process that replaces the immunoglobulin (Ig) constant region for the isotype that can best protect against the pathogen. Dysregulation of CSR can cause self-reactive BCRs and B cell…
Foxo transcription factors integrate extrinsic signals to regulate cell division, differentiation and survival, and specific functions of lymphoid and myeloid cells. Here we showed the absence of Foxo1 severely curtailed the development of…
Mohamad Karimi, Associate Professor | Cited by 2,700 | of Shiraz University of Medical Sciences, Shiraz (SUMS) | Read 185 publications | Contact Mohamad Karimi
We studied germinal center responses and HIV-1 antibody development in rhesus macaques (RMs) immunized with sequential CH505 gp120 envelopes (Envs), with or without anti-CD25 monoclonal antibody (mAb).
Germinal centers (GCs) are the primary sites of clonal B cell expansion and affinity maturation, directing the production of high-affinity antibodies. This response is a central driver of pathogenesis in autoimmune diseases, such as…