Glucocorticoid hormones control diverse physiological processes, including metabolism and immunity, by activating the major glucocorticoid receptor (GR) isoform, GRα. However, humans express an alternative isoform, human (h)GRβ, that acts…
DJ-1/PARK7, a cancer- and Parkinson's disease (PD)-associated protein, protects cells from toxic stresses. However, the functional basis of this protection has remained elusive. We found that loss of DJ-1 leads to deficits in NQO1 [NAD(P)H…
Carboxymethylation of proteins is a highly conserved means of regulation in eukaryotic cells. The protein phosphatase 2A (PP2A) catalytic (C) subunit is reversibly methylated at its carboxyl terminus by specific methyltransferase and…
Glucocorticoids are primary stress hormones that regulate many physiological processes, and synthetic derivatives of these molecules are widely used in the clinic. The molecular factors that govern tissue specificity of glucocorticoids…
Mutational inactivation of BRCA1 confers a cumulative lifetime risk of breast and ovarian cancers. However, the underlying basis for the tissue-restricted tumor-suppressive properties of BRCA1 remains poorly defined.
Early Look Thursday, February 27, 2025 Futures Up/Down % Last Dow 96.00 0.22% 43,602 S&P 500 34.25 0.57% 6,005 Nasdaq 132.00 0.62% 21,319 U.S. stock futures are looking higher overnight, getting a boost from shares of NVDA which reported a…
In particular, the bit that's supposed to be NH2 has 3 hydrogens on it. — Preceding unsigned comment added by 194.39.218.10 (talk) 15:07, 22 October 2012 (UTC) Sorry, scrub that.
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Před 9 měsíciAt NorthC, we're leading the way in leveraging hydrogen as a low-carbon energy source. Our facilities in Groningen and Eindhoven are already harnessing green hydrogen for standby power, with cutting-edge innovations like: 𝐏𝐄𝐌 𝐅𝐮𝐞𝐥 𝐂𝐞𝐥𝐥𝐬 in…