Here, we comprehensively profile transducer coupling of this receptor, discover potential non-canonical signaling pathways, and determine the cryoelectron microscopy (cryo-EM) structure in complex with the chemokine CCL7.
The division of the geographical area of Macedonia became a major point of contention among the allies. Greece had captured Thessaloniki and much of western Macedonia, while Serbia had captured most of northern Macedonia, both areas also…
La sociedad actual fue creada el 23 de diciembre de 2009, mientras que la sociedad histórica desapareció el 21 de enero de 2011 al ser absorbida junto con BA Holdco por International Consolidated Airlines Group. [2 ] [3 ] [4 ] Tiene su sede…
Abstract. Hypoxia-inducible factor 1 (HIF-1) activates transcription of genes encoding angiogenic growth factors, which are secreted by hypoxic cells and s
Mechanistically, SESN2 inhibited the expression of sterol regulatory element-binding transcription factor 1 (Srebp1) and interacted with Srebp cleavage-activating protein (SCAP) to deactivate Srebp1-mediated transcription for lipogenesis.
The AMP-activated protein kinase (AMPK) regulates cellular energy homeostasis by sensing the metabolic status of the cell. AMPK is regulated by phosphorylation and dephosphorylation as a result of changing AMP/ATP levels and by removal of…
The type 2 ryanodine receptor (RyR2) is a Ca2+ release channel on the endoplasmic reticulum (ER) of several types of cells, including cardiomyocytes and pancreatic β cells. In cardiomyocytes, RyR2-dependent Ca2+ release is critical for
In this study, we demonstrate a method for rapidly identifying bacterial effector genes and gene products from human commensal bacteria. Identification of specific effector genes and small molecules improves our understanding of how…