Lentivirus vectors based on human immunodeficiency virus (HIV) type 1 (HIV-1) constitute a recent development in the field of gene therapy. A key property of HIV-1-derived vectors is their ability to infect nondividing cells.
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Long interspersed elements 1 (LINE-1) occupy at least 17% of the human genome and are its only active autonomous retrotransposons. However, the host factors that regulate LINE-1 retrotransposition are not fully understood.
The human Samhd1 protein potently restricts lentiviral infection in dendritic cells and monocyte/macrophages, but is antagonized by the primate lentiviral protein Vpx which targets Samhd1for degradation.
El virus de la inmunodeficiencia humana (VIH) es un lentivirus (un género de la familia retrovirus) que causa la infección por VIH. [1 ]Se trata de un virus que, en promedio, en 10 años en países desarrollados o en 5 años en países con…
HTML Format - At a Glance Climate change heightens the risks of wildfires and other natural disasters. As insurance payouts for losses sustained in those disasters increase and as uncertainty about future losses grows, people in many high…