Changes in histone modifications are an attractive model through which environmental signals, such as diet, could be integrated in the cell for regulating its lifespan. However, evidence linking dietary interventions with specific…
Hajime Ogino, Professor, Director of Amphibian Research Center | Cited by 3,611 | of Hiroshima University, Hiroshima (HU) | Read 101 publications | Contact Hajime Ogino
Business Owner · I have been in the computer field for over 50 years in both military and civilian capacities. During that time, I have worked in every area of the computer field: Computer Operations, Tech Support, Security, Programming…
There is sexual dimorphism of skeletal muscle, the most obvious feature being the larger muscle mass of men. The molecular basis for this difference has not been clearly defined. To identify genes that might contribute to the relatively…
The substrates used to modify nucleic acids and chromatin are affected by nutrient availability and the activity of metabolic pathways. Thus, cellular metabolism constitutes a fundamental component of chromatin status and thereby of genome…
The simultaneous measurement of multiple modalities represents an exciting frontier for single-cell genomics and necessitates computational methods that can define cellular states based on multimodal data.
Dicer1-deficient mouse ES cells have often been found to be deficient in DNA methylation. These observations have been predominantly of localized and dispersed repeats which constitute the large majority of methylated CpG dyads in the…
The data support a model whereby inactivation of specific regulatory elements, rather than a simple chromosome-wide separation from transcription machinery, governs gene silencing over the Xi.