[h]igh-profile outbreaks of violence involving fans are much rarer today than they were 20 or 30 years ago. The scale of trouble now compared to then doesn't bear comparison – either in terms of the number of people involved or the level of…
Esto incluye las definiciones 4K (2160p), 8K (4320p) y 16K (8640p), [5 ] [6 ] [7 ] [8 ] [9 ] las cuales son tres señales digitales de video, propuestas por el antes mencionado NHK y aprobadas por la Unión Internacional de Telecomunicaciones…
IMGT, the international ImMunoGeneTics information system, created in 1989, by Marie-Paule Lefranc (Université de Montpellier and CNRS), marked the advent of immunoinformatics, a new science which emerged at the interface between…
A small molecule drug promoting miRNA processing induces alternative splicing of MdmX transcript and rescues p53 activity in human cancer cells overexpressing MdmX protein.
A cardinal feature of systemic lupus erythematosus (SLE) is the development of autoantibodies. The first autoantibodies described in patients with SLE were those specific for nuclei and DNA, but subsequent work has shown that individuals…
Las siguientes tablas muestran los caracteres del Alfabeto Fonético Internacional (AFI) utilizados en los artículos de Wikipedia para representar la pronunciación del idioma inglés.
Class switch recombination (CSR) is a DNA recombination process that replaces the immunoglobulin (Ig) constant region for the isotype that can best protect against the pathogen. Dysregulation of CSR can cause self-reactive BCRs and B cell…
MYC contributes to the pathogenesis of a majority of human cancers, yet strategies to modulate the function of the c-Myc oncoprotein do not exist. Toward this objective, we have targeted MYC transcription by interfering with chromatin…
We show that Parp3 facilitates the repair of AID-induced DNA damage and controls AID levels on chromatin. We propose that Parp3 protects antibody genes from sustained AID-dependent DNA damage.
Los anticuerpos, (en la ciencia inmunoglobulinas Ig) son glucoproteínas del tipo gamma globulina. Pueden encontrarse de forma soluble en la sangre y los otros fluidos corporales de los vertebrados, disponiendo de una forma idéntica que actúa…