ISO 3166-1 [1 ] es la primera parte del estándar internacional de normalización ISO 3166, publicado por la Organización Internacional de Normalización (ISO), que proporciona códigos para los nombres de países y otras dependencias…
The metabolism of poly(ADP-ribose) (PAR) is critical for genomic stability in multicellular eukaryotes. Here, we show that the failure to degrade PAR by means of disruption of the murine poly(ADP-ribose) glycohydrolase (PARG) gene…
Pedobacter saltans Steyn et al. 1998 is one of currently 32 species in the genus Pedobacter within the family Sphingobacteriaceae. The species is of interest for its isolated location in the tree of life.
Furthermore, we demonstrate that this effect of lactic acid is mediated by hypoxia-inducible factor 1a (HIF1a). Finally, we show that the lactate-induced expression of arginase 1 by macrophages has an important role in tumour growth.
PRMT1 is a key enzyme responsible for protein arginine methylation, which regulates various cellular processes. However, its physiological significance at whole-body level remains unknown due to embryonic lethality of Prmt1-null mice.
We previously reported brown adipocytes can proliferate even after differentiation. To test the involvement of mature adipocyte proliferation in cell number control in fat tissue, we generated transgenic (Tg) mice over-expressing cell-cycle…