Endothelium-leukocyte interaction is critical for inflammatory responses. Whereas the tissue microenvironments are often acidic at inflammatory sites, the mechanisms by which cells respond to acidosis are not well understood.
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Recently, the G protein-coupled receptor GPR30 has been identified as a novel oestrogen receptor (ER). The distribution of the receptor has been thus far mapped only in the rat central nervous system.
Cannabis (/ ˈ k æ n ə b ɪ s/ ) [2 ] is a genus of flowering plants in the family Cannabaceae that is widely accepted as being indigenous to and originating from the continent of Asia. [3 ] [4 ] [5 ] However, the number of species is…
Accumulating evidence suggested that an orphan G protein-coupled receptor (GPR)30, mediates nongenomic responses to estrogen. The present study was performed to investigate the molecular mechanisms underlying GPR30 function.
AIM: To investigate the effect of short-chain fatty acids (Scfas) on production of prostaglandin E2 (PGE2), cytokines and chemokines in human monocytes. Methods: Human neutrophils and monocytes were isolated from human whole blood by using…