Resveratrol induces mitochondrial biogenesis and protects against metabolic decline but whether SIRT1 mediates these benefits is the subject of debate. To circumvent the developmental defects of germ-line SIRT1 knockouts, we have developed…
In this review, we will discuss small molecules that recent evidence suggests may be capable of improving health and extending lifespan in mammals, focusing particularly on resveratrol, rapamycin, and metformin.
In heart failure patients the consumption of (-)epicatechin ((-Epi)-rich cocoa can restore skeletal muscle (SkM) mitochondrial structure and decrease biomarkers of oxidative stress.
Obesity-linked type 2 diabetes is one of the paramount causes of morbidity and mortality worldwide, posing a major threat on human health, productivity, and quality of life. Despite great progress made towards a better understanding of the…