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Rat cardiac fibroblasts (CF) express multiple adenosine (ADO) receptors. Pharmacological evidence suggests that activation of A2 receptors may inhibit collagen synthesis via adenylyl cyclase-induced elevation of cellular cAMP.
Cardiac fibroblasts are the most populous non-myocyte cell type within the mature heart and are required for extracellular matrix synthesis and deposition, generation of the cardiac skeleton, and to electrically insulate the atria from the…
Myopia, also known as near-sightedness and short-sightedness, [7 ] is an eye condition [8 ] [9 ] where light from distant objects focuses in front of, instead of on, the retina. [1 ] [2 ] [10 ] As a result, distant objects appear blurry…
In addition to possible direct effects of resveratrol on SIRT1 activity, resveratrol also activates AMPK. It has been speculated that this might occur via inhibition of electron transport, with a consequent rise in ATP [5].
Players without a club may be signed at any time, clubs may sign players on loan dependent on their league's regulations, and clubs may sign a goalkeeper on an emergency loan if they have no registered senior goalkeeper available.
Resveratrol induces mitochondrial biogenesis and protects against metabolic decline but whether SIRT1 mediates these benefits is the subject of debate. To circumvent the developmental defects of germ-line SIRT1 knockouts, we have developed…
Cancer stem cells (CSCs) are cancer cells (found within tumors or hematological cancers) that possess characteristics associated with normal stem cells, specifically the ability to give rise to all cell types found in a particular cancer…
A characteristic feature of the human airway epithelium is the presence of ciliated cells bearing motile cilia, specialized cell surface projections containing axonemes comprised of microtubules and dynein arms, which provide ATP-driven…