Activity of KCNQ (Kv7) channels requires binding of phosphatidylinositol 4,5-bisphosphate (PIP2) from the plasma membrane. We give evidence that Mg2+ and polyamines weaken the KCNQ channel–phospholipid interaction.
Hydrogen peroxide is a chemical compound with the formula H2O2. In its pure form, it is a very pale blue [5 ] liquid that is slightly more viscous than water.
L. Y. Li currently works at the School of Space and Environment, Beihang University (BUAA). Their current project is 'Space Physics and Space Weather'.
What key dialectal differences characterize Akkadian development?The study identifies two major dialectal variations in Akkadian: Babylonian in the south and Assyrian in the north, distinguished by phonological and morphological features. For instance, Babylonian was more cosmopolitan, influencing even Assyrian royal inscriptions.What notable texts demonstrate linguistic richness in Old Babylonian?Old Babylonian possesses extensive literary texts, including the Laws of Hammurabi and various royal inscriptions, totaling approximately 40,000 lines preserved. These texts showcase a high level of grammatical uniformity and literary quality during 2000-1500 BC.How did Akkadian influence spread during the Middle Babylonian period?Akkadian served as a lingua franca across the ancient Near East during the Middle Babylonian period (c. 1500-1200 BC), evident from over 350 letters found at Tell el-Amarna. This included diplomatic exchanges among states like Babylonia, Assyria, and Egypt.
We examined desensitization by acetylcholine (ACh) and nicotine at the rat α4β2 neuronal nicotinic receptor stably expressed in HEK cells. For both agonists, the decay in response due to desensitization (‘onset’) was best fitted by the sum…
Objective To assess the effect of targeting intensive glycaemic control versus conventional glycaemic control on all cause mortality and cardiovascular mortality, non-fatal myocardial infarction, microvascular complications, and severe…